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yjeA [2017-08-24 18:05:56]
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yjeA [2017-08-24 18:05:56]

peptidoglycan deacetylase C
locus
BSU12100
pI
9.10
mw
53.67 kDa
protein length
467 aa Sequence Blast
gene length
1401 bp Sequence Blast
function
cell wall modification
product
polysaccharide deacetylase C
essential
no
synonyms
pdaC
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.5|Cell wall/ other]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • Gene

    Coordinates
    1,281,128 → 1,282,531

    Phenotypes of a mutant

  • sensitive to lysozyme treatment [Pubmed|22277649]

    • The protein

    Catalyzed reaction/ biological activity

  • deacetylates N-acetylmuramic acid (MurNAc) but not GlcNAc from peptidoglycan [Pubmed|22277649]

    • Protein family

  • polysaccharide deacetylase family (according to Swiss-Prot)

    • Paralogous protein(s)

  • [protein|2E2D21BEA164C7EB93B6A3F3C990ABD475920A81|YheN]

    • Structure

  • [PDB|2C1G] (the NodB domain, from Streptococcus pneumoniae, 47% identity) [pubmed|16221761]
  • [PDB|3S5T] (the DUF3298 domain, from Bacteroides fragilis, 27% identity) [pubmed|16221761]

    • Expression and Regulation

    Operons

    genes
    [gene|603E226CE488A25C4E28A6A7363CCD65BE64BB21|pdaC]
    description
    [pubmed|22383849]

    regulatory mechanism

  • [protein|7F340423A34CE40D1F1AA8D373F7C4B859A6496D|WalR]: repression, in [regulon|7F340423A34CE40D1F1AA8D373F7C4B859A6496D|WalR regulon]
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    Biological materials

    Mutant

  • MGNA-A355 (yjeA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/355 NBRP B. subtilis, Japan]

    • References

  • 17878218,17581128,22277649,23199363,26883633,16221761